Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1–7 randomised controlled trials
The study examined the effects of semaglutide on kidney function and safety in a large, broad type 2 diabetes population. eGFR and UACR were also anal...
Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials
Melanocortin 4 receptor (MC4R) receptor plays a part in body weight regulation. Severe early-onset obesity can be caused by biallelic variants in gene...
Effects of empagliflozin on first and recurrent clinical events in patients with type 2 diabetes and atherosclerotic cardiovascular disease: a secondary analysis of the EMPA-REG OUTCOME trial
EMPA-REG OUTCOME trial was a randomized, double-blind, non-inferiority trial of patients with type 2 diabetes and atherosclerotic cardiovascular disea...
2-year remission of type 2 diabetes and pancreas morphology: a post-hoc analysis of the DiRECT open-label, cluster-randomised trial
The pancreas is small and irregular in shape in people with type 2 diabetes. remission of the disease should restore normal pancreas morphology. This...
Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial
Testosterone treatment for 2 years reduced the proportion of participants with type 2 diabetes beyond the effects of a lifestyle programme. The treatm...
Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial
The multicentre, double-blind, placebo-controlled, randomized trial was done at 386 study sites in 21 countries. The relative risk reduction for the p...
Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature
Phaeochromocytoma or paraganglioma in pregnant women can lead to severe complications and death. Unrecognized and untreated PPGL was associated with a...
Effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate in patients with heart failure (Empire HF Renal): a prespecified substudy of a double-blind, randomised, placebo-controlled trial
SGLT2 inhibitors are a promising treatment option in patients with heart failure. The Empire HF trial is registered with ClinicalTrials.gov and EudraC...
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