Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease
Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer's disease (AD) The kidney is thought to be responsible fo...
Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes
High expression variants of C4, a gene of the innate immune complement system, were shown to confer susceptibility to schizophrenia. How elevated C4 e...
Neural correlates of visuospatial processing in migraine: does the pain network help?
Migraine patients maintained a preserved behavioural performance during the angle discrimination task. They performed less correctly in the colour dis...
Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice
Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) It results in d...
Comparative efficacy and acceptability of psychological interventions for the treatment of adult outpatients with anorexia nervosa: a systematic review and network meta-analysis
We searched Cochrane CENTRAL, CINAHL, MEDLINE, and PsychINFO for published and unpublished literature from inception until March 20, 2020. Primary out...
Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study
Cognitive impairment associated with schizophrenia predicts poor functional outcomes. Currently, no approved pharmacotherapy is available. This study...
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
E3-ubiquitin ligase Cullin3 (Cul3) is a high confidence risk gene for autism spectrum disorder (ASD) and developmental delay (DD) We generated a hapl...
Identification of Neurensin-2 as a novel modulator of emotional behavior
Recent studies have suggested a key role for GABAergic interneurons in depression. These interneurons highly express the chromatin-remodeler SMARCA3 w...
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