Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts
Treatment-resistant depression is a major contributor to the disability caused by a major depressive disorder (MDD) Primary care electronic health rec...
Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit
High comorbidity between obesity and mental disorders, such as depression and anxiety, often exacerbates metabolic and neurological symptoms. Neurons...
Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments
Transcranial magnetic stimulation (TMS) can be used to examine and modulate neural systems and related cognitive and behavioral functions in humans.
Improving Suicide Prevention Through Evidence-Based Strategies: A Systematic Review
Teaching youths about depression and suicidal behavior can prevent suicide. Ketamine reduces suicidal ideation in hours but is untested for suicidal b...
Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis
The study compared relapse prevention and acceptability of long-acting injectable (LAI) antipsychotics in the maintenance treatment of adults with non...
Association Between Benzodiazepine or Z-Drug Prescriptions and Drug-Related Poisonings Among Patients Receiving Buprenorphine Maintenance: A Case-Crossover Analysis
Benzodiazepine and Z-drug use is linked with drug-related poisonings among patients receiving buprenorphine maintenance treatment. Buprenorphine's ass...
Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial
This is the first randomized placebo-controlled trial to test the effect of the KCQ2-2 positive modulator ezogabine on reward circuit activity and out...
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Adolescent depression is prevalent and associated with significant morbidity and mortality. 17 adolescents with a diagnosis of major depressive disord...