Genetic and clinical characteristics of treatment-resistant depression using primary care records in two UK cohorts

Treatment-resistant depression is a major contributor to the disability caused by a major depressive disorder (MDD) Primary care electronic health rec...

Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit

High comorbidity between obesity and mental disorders, such as depression and anxiety, often exacerbates metabolic and neurological symptoms. Neurons...

Improving Suicide Prevention Through Evidence-Based Strategies: A Systematic Review

Teaching youths about depression and suicidal behavior can prevent suicide. Ketamine reduces suicidal ideation in hours but is untested for suicidal b...

Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis

The study compared relapse prevention and acceptability of long-acting injectable (LAI) antipsychotics in the maintenance treatment of adults with non...

Association Between Benzodiazepine or Z-Drug Prescriptions and Drug-Related Poisonings Among Patients Receiving Buprenorphine Maintenance: A Case-Crossover Analysis

Benzodiazepine and Z-drug use is linked with drug-related poisonings among patients receiving buprenorphine maintenance treatment. Buprenorphine's ass...

Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial

This is the first randomized placebo-controlled trial to test the effect of the KCQ2-2 positive modulator ezogabine on reward circuit activity and out...

Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial

Adolescent depression is prevalent and associated with significant morbidity and mortality. 17 adolescents with a diagnosis of major depressive disord...