Chronic low-dose intravenous immunoglobulins as steroid-sparing therapy in myasthenia gravis
Intravenous immunoglobulin (IVIg) has been proven beneficial in myasthenic crisis, but their role as maintenance therapy is unclear. The aim of this...
LeSCoD: a new clinical scale for the detection of Lewy body disease in neurocognitive disorders
LeSCoD for Lewy body Screening scale in Cognitive Disorders. 128 patients with Lewy bodies, Alzheimer's disease, and dementia were prospectively enrol...
Brain hypometabolic changes in 14 adolescent–adult patients with Niemann–Pick disease type C assessed by 18F-fluorodeoxyglucose positron emission tomography
Niemann Pick disease type C (NPC) is a rare progressive neurovisceral lysosomal disorder caused by autosomal recessive mutations in the NPC1 or NPC2 g...
Tranexamic acid in patients with intracerebral haemorrhage (STOP-AUST): a multicentre, randomised, placebo-controlled, phase 2 trial
Tranexamic acid decreases haemorrhage in conditions such as acute trauma and menorrhoea. Between March 1, 2013, and Aug 13, 2019, we enrolled and rand...
Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study
Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the tranStHyretin (TTR) gene. The globa...
Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial
Prednisone is commonly used for short-term therapy of episodic cluster headaches before preventive medication such as verapamil becomes effective. We...
Forecasting seizure risk in adults with focal epilepsy: a development and validation study
Evidence from studies using chronic EEG (cEEG) revealed that epileptic brain activity shows robust cycles. Forecasts with a shorter horizon of 1 h, po...
The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data
There is a strong biological rationale for early decompression of the injured spinal cord, but the influence of the timing of surgical decompression f...
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