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Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial

Degenerative cervical myelopathy is the most common form of non-traumatic spinal cord injury. This multicentre, double-blind, placebo-controlled, rand...

Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study

Prehospital stroke scales have been proposed to select patients with large-vessel occlusion for direct transport. The NIHSS as assessed by a clinician...

Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study

Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the alpha-synucleinopathies Parkinson's disease...

Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial

Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. Progressive supranuclear palsy is a neurodegenerative diso...

MRI Brain Templates of the Male Yucatan Minipig

The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently, however, there is a lack o...

The impact of the COVID-19 pandemic on radiotherapy services in England, UK: a population-based study

In 2020, mean weekly radiotherapy courses fell by 19% in April, 6% in May, and 11% in June compared with corresponding months in 2019. The largest red...

Identification of novel risk loci and causal insights for sporadic Creutzfeldt-Jakob disease: a genome-wide association study

Human prion diseases are rare and usually rapidly fatal neurodegenerative disorders. Most common is sporadic Creutzfeldt-Jakob disease (sCJD) Variants...

Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study

Since 2015, the arthropod-borne viruses (arboviruses) have spread across the Americas causing outbreaks. These outbreaks have been accompanied by incr...

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