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Sofosbuvir plus ribavirin and sofosbuvir plus ledipasvir in patients with genotype 1 or 3 hepatitis C virus and severe renal impairment: a multicentre, phase 2b, non-randomised, open-label study

There is a medical need for highly effective, safe, and well-tolerated treatments for patients infected with hepatitis C virus (HCV) Eight patients ha...

Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis

Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders. Community prevalence appears to vary widely between different cou...

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial

LIR! C trial showed laparoscopic ileocaecal resection is a cost-effective treatment for Crohn's disease. It has similar quality-of-life outcomes to tr...

Standard gastroenterologist versus multidisciplinary treatment for functional gastrointestinal disorders (MANTRA): an open-label, single-centre, randomised controlled trial

Outcomes were assessed at clinic discharge or 9 months after the initial visit. The primary outcome was a score of 4 or 5 on a 5-point Likert scale as...

Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study

Liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection. Increased age and presence of comorbidit...

Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

Lubiprostone was well tolerated and reduced the levels of liver enzymes in patients with NAFLD and constipation. The most common adverse event was dia...

Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden

The use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD) Data for adults are mixed and smaller investigati...

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

Non-invasive tests that can identify patients with non-alcoholic steatohepatitis (NASH) at higher risk of disease progression are lacking. We report t...

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