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Safety and activity of trifluridine/tipiracil and ramucirumab in previously treated advanced gastric cancer: an open-label, single-arm, phase 2 trial

The study followed patients with unresectable advanced gastric cancer or gastro-oesophageal junction adenocarcinoma. Serious treatment-related adverse...

Assessment of hepatic steatosis by controlled attenuation parameter using the M and XL probes: an individual patient data meta-analysis

Most research on HCV disease burden among women aged 15–49 years focuses on pregnant women. We aimed to estimate the global prevalence of viraemic HCV...

Global prevalence of hepatitis C virus in women of childbearing age in 2019: a modelling study

Treatment for infection with hepatitis C virus (HCV) during pregnancy has not yet been approved. Most research on HCV disease burden among women aged...

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study

Isocitrate dehydrogenase 1 (IDH1) mutations occur in approximately 13% of patients with intrahepatic cholangiocarcinoma. 185 patients were randomly as...

Cytoreductive surgery and HIPEC for malignant ascites from colorectal cancer - a randomized study

The efficacy of different timings of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in controlling malignant ascit...

Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism

Pharmacological ascorbate (P-AscH-, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Studies in pancreatic...

Randomised clinical trial: palliative long-term abdominal drains vs large-volume paracentesis in refractory ascites due to cirrhosis

Palliative care remains suboptimal in end-stage liver disease. Study assessed palliative long-term abdominal drains in liver disease to determine recr...

Randomised clinical trial: standard of care versus early-transjugular intrahepatic porto-systemic shunt (TIPSS) in patients with cirrhosis and oesophageal variceal bleeding

Early-transjugular intrahepatic porto-systemic shunt (TIPSS) recommended in international guidelines for high-risk patients with oesophageal variceal...

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