Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism
Pharmacological ascorbate (P-AscH-, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Studies in pancreatic cancer have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease burden. In vitro and in vivo, P-AScH- significantly decreased formation of ascites, tumor burden over time, circulating tumor cells, and hepatic metastases.
