Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 1988 to 2012 worldwide
Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 198...
Bariatric Surgery Reduces Cancer Risk in Adults with Nonalcoholic Fatty Liver Disease and Severe Obesity
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and an increased risk of cancer. We investigated the effect of bariatric surgery o...
Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer
The authors conducted a patient-centered functional genomics platform that includes approximately 200 genes. Administration of KPT-8602, an XPO1 inhib...
Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer
Neutrophils can increase DNA double-strand breaks (DSB) burden and promote genomic instability in colorectal cancer. They can also promote HR deficien...
Familial burden and other clinical factors associated with various types of cancer in individuals with Lynch syndrome
LS is associated with increased risks of various gastrointestinal, gynecologic, genitourinary, and other cancers. Many clinical practice guidelines re...
A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer
Study: Translates tissue-based biomarkers into a blood-based liquid biopsy for noninvasive detection of lymph node metastasis. The Risk-stratification...
Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine
Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Pruritogenicity of LPC, LPA's precursor, was...
BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes
Pancreatic ductal adenocarcinoma (PDAC) has different subtypes and their correlation with patient outcomes. B-cell CLL/lymphoma 3 (BCL3) was significa...
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