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BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

Intestinal regeneration is underpinned by dedifferentiation and cell plasticity. We spatiotemporally mapped BMP signaling in mouse and human regenerat...

Nab-paclitaxel plus gemcitabine versus nab-paclitaxel plus gemcitabine followed by FOLFIRINOX induction chemotherapy in locally advanced pancreatic cancer (NEOLAP-AIO-PAK-0113): a multicentre, randomised, phase 2 trial

We aimed to compare the efficacy and safety of nab-paclitaxel plus gemcitabine with nab-Paclitaxel plus gemcitabine. Adults (aged 18–75 years) with an...

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Radical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. Serious adverse events asso...

Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study

The study aims to investigate the impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England. By October 2020, th...

Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis

Sulfation is a conjugation reaction essential for numerous biochemical and cellular functions in mammals. The lower expression of PAPSS2 in colon canc...

Increasing Rates of Opioid Prescriptions for Gastrointestinal Diseases in the United States

Pain control is an important management approach for many gastrointestinal conditions. Opioid prescription rates for the gastrointestinal disease incr...

Sequential endoscopist-driven phone calls improve the capture rate of adverse events after ERCP: a prospective study

ERCP is a high-risk endoscopic procedure, yet reports of ERCP-related adverse events are largely limited to early adverse events based on immediate po...

Salvage endoscopic resection after definitive chemoradiotherapy for esophageal cancer: a Western experience

Definitive chemoradiotherapy is increasingly used as a nonsurgical treatment for esophageal cancer. Salvage endoscopic resection has emerged as a prom...

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