A systematic review and meta-analysis of obesity and COVID-19 outcomes

Some studies report that obesity is associated with more severe symptoms following SARS-CoV-2 infection and worse COVID-19 outcomes. It is uncertain w...

Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial

Degenerative cervical myelopathy is the most common form of non-traumatic spinal cord injury. This multicentre, double-blind, placebo-controlled, rand...

Effectiveness of fibroblast growth factor 23 lowering modalities in chronic kidney disease: a systematic review and meta-analysis

High fibroblast growth factor 23 (FGF23) level in patients with chronic kidney disease is associated with increased cardiovascular disease and mortali...

Safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of the oral TYK2 inhibitor PF-06826647 in participants with plaque psoriasis: a phase 1, randomised, double-blind, placebo-controlled, parallel-group study

Tyrosine kinase 2 (TYK2) signaling has previously shown therapeutic potential in the treatment of psoriasis. The primary objective of this study was t...

Health Services Use by Children in the Welfare System Who Died by Suicide

Suicide decedents with a history of child welfare system involvement could be targeted for prevention strategies. The study included youth aged 5 to 2...

Treatment with zoledronate subsequent to denosumab in osteoporosis: a 2‐year randomized study

The study included 61 postmenopausal women and men above 50 years discontinuing denosumab after 4.6±1.6 years. After 12 months, lumbar spine BMD decre...

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics

Pre-clinical research in the development of nanoparticle therapeutic delivery is being undertaken in many fields of reproductive medicine. Non-hormona...

Comparison of eight prehospital stroke scales to detect intracranial large-vessel occlusion in suspected stroke (PRESTO): a prospective observational study

Prehospital stroke scales have been proposed to select patients with large-vessel occlusion for direct transport. The NIHSS as assessed by a clinician...

Departments

Recent Posts