Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study

Liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection. Increased age and presence of comorbidit...

Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

Lubiprostone was well tolerated and reduced the levels of liver enzymes in patients with NAFLD and constipation. The most common adverse event was dia...

Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden

The use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD) Data for adults are mixed and smaller investigati...

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

Non-invasive tests that can identify patients with non-alcoholic steatohepatitis (NASH) at higher risk of disease progression are lacking. We report t...

Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial

Cobitolimod is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9) It's a promising novel therapeutic targe...

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

Previous estimates of the magnitude of this issue have not accounted for ongoing inflammation as the potential cause. Of 3370 studies identified, 27 w...

Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis

Tenofovir disoproxil fumarate and entecavir differ in their association with the risk of hepatocellular carcinoma. Treatment should be guided by patie...

Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis

WHO has set targets for hepatitis C virus (HCV) elimination by 2030. We looked at studies published and listed on MEDLINE or Embase between 2000 and 2...

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