Elevated expression of complement C4 in the mouse prefrontal cortex causes schizophrenia-associated phenotypes

High expression variants of C4, a gene of the innate immune complement system, were shown to confer susceptibility to schizophrenia. How elevated C4 e...

Cortical diffusion kurtosis imaging and thalamic volume are associated with cognitive and walking performance in relapsing–remitting multiple sclerosis

In MS, pronounced neurodegeneration manifests itself as cerebral gray matter (GM) atrophy. The study looked at the relationship between morphological...

Chronic low-dose intravenous immunoglobulins as steroid-sparing therapy in myasthenia gravis

Intravenous immunoglobulin (IVIg) has been proven beneficial in myasthenic crisis, but their role as maintenance therapy is unclear. The aim of this...

Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice

Heterozygous mutation of chromodomain helicase DNA binding protein 8 (CHD8) is strongly associated with autism spectrum disorder (ASD) It results in d...

Brain hypometabolic changes in 14 adolescent–adult patients with Niemann–Pick disease type C assessed by 18F-fluorodeoxyglucose positron emission tomography

Niemann Pick disease type C (NPC) is a rare progressive neurovisceral lysosomal disorder caused by autosomal recessive mutations in the NPC1 or NPC2 g...

British cycling team - CORE principles and healthcare application

The core principle of British cycling teams strategy which produced exemplary results in Olympics has many learnings to taking the team towards the go...

Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gains access to the CNS. We investigated the brain tissue of patien...

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