Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

There has been a considerable increase in thyroid cancer incidence among adults in several countries in the past three decades. Rapid increases in inc...

Safety and activity of trifluridine/tipiracil and ramucirumab in previously treated advanced gastric cancer: an open-label, single-arm, phase 2 trial

The study followed patients with unresectable advanced gastric cancer or gastro-oesophageal junction adenocarcinoma. Serious treatment-related adverse...

Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

New risk model to assess the benefits of adhering to a healthy lifestyle in individuals with a high genetic risk. The polygenic risk score derived fro...

Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial

BRCA1 or BRCA2-mutated breast cancers are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. BROCADE3 was a randomized, double-blind, placebo...

Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm, phase 2 trial

Survival outcomes for patients with recurrent or advanced cervical cancer are poor. GX-188E vaccination has been shown to induce human papillomavirus...

The effect of clinical decision making for initiation of systemic anticancer treatments in response to the COVID-19 pandemic in England: a retrospective analysis

Cancer services worldwide had to adapt in response to the COVID-19 pandemic to minimize risk to patients and staff. We aimed to assess the national im...

First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial

First-line nivolumab plus ipilimumab has shown improved overall survival in patients with advanced non-small-cell lung cancer (NSCLC) The most common...

Comparison of breast cancer and cervical cancer stage distributions in ten newly independent states of the former Soviet Union: a population-based study

More than 50% of breast cancer cases across the region were at stages I–II. The proportion of stage I cases was highest in the screening age group of...

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