Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018

Across 26 current ACC/AHA guidelines, 8.5% of recommendations were classified as LOE A. When comparing current guidelines with prior versions, the pro...

Published Articles Reporting Studies by Industry Employees on Interventional Cardiology Devices

Findings were based on studies published between January 1, 2010, and December 31, 2012. Authors with IEAs were significantly more likely to report po...

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes

The aim was to identify differential CAV1 versus CAV3 protein interactions and to define the molecular basis of cardiacCAV3 loss-of-function. McT1 rep...

Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure

Diaphragm weakness impairs quality of life, exercise capacity, and survival in patients with chronic heart failure (CHF) and reduced left ventricular...

Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19: JACC State-of-the-Art Review

Endothelial injury and microvascular/macrovascular thrombosis are common pathophysiological features of coronavirus disease-2019 (COVID-19). We search...

Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead ECG and Help Identify Those at Risk of Atrial Fibrillation–Related Stroke

Atrial fibrillation (AF) is associated with substantial morbidity, especially when it goes undetected. Deep neural networks were trained to predict ne...

Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device

Heart rate–corrected QT interval (QTc) prolongation can predispose to ventricular arrhythmias and sudden cardiac death. Currently, QTc assessment and...