Effect of dapagliflozin as an adjunct to insulin over 52 weeks in individuals with type 1 diabetes: post-hoc renal analysis of the DEPICT randomised controlled trials
Dapagliflozin was found to improve glycaemic control and body weight without an increase in the risk of hypoglycemia in the DEPICT studies. No notable...
Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial
Metformin is increasingly being used in women with type 2 diabetes during pregnancy. Little data exist on the benefits and harms of metformin use on p...
Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study
Deaths in people with type 1 and type 2 diabetes rose sharply during the initial COVID-19 pandemic in England. Male sex, older age, renal impairment,...
Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study
Diabetes has been associated with COVID-19-related mortality. The absolute and relative risks for type 1 and type 2 diabetes are unknown. We assessed...
Effects of canagliflozin on anaemia in patients with type 2 diabetes and chronic kidney disease: a post-hoc analysis from the CREDENCE trial
Sodium-glucose co-transporter 2 inhibitors might enhance erythropoiesis and increase red blood cell mass. We assessed the effects of canagliflozin ver...
Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: a population-based cohort study
Adrenal tumors are commonly encountered in clinical practice. Adrenal tumor standardized incidence rates increased 10 times from 1995 to 2017. The pre...
Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1–7 randomised controlled trials
The study examined the effects of semaglutide on kidney function and safety in a large, broad type 2 diabetes population. eGFR and UACR were also anal...
Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials
Melanocortin 4 receptor (MC4R) receptor plays a part in body weight regulation. Severe early-onset obesity can be caused by biallelic variants in gene...
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