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Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training

Simulator training significantly improved performance on simulated cases compared with patient-based training. Subjects had higher completion rates an...

Efficacy and safety of certolizumab pegol in an unselected crohn's disease population: 26-week data of the FACTS II survey

Certolizumab pegol (Cimzia, CZP) was approved for the treatment of Crohn's disease (CD) patients in 2007 in Switzerland. This prospective phase IV stu...

Randomized phase III trial in elderly patients comparing LV5FU2 with or without irinotecan for first-line treatment of metastatic colorectal cancer (FFCD 2001-02)

Metastatic colorectal cancer (mCRC) frequently occurs in elderly patients. The benefit of first-line CT intensification remains an issue. Four arms we...

Second-line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine-platinum combination: A large multicenter study by the Association des Gastro-Entérologues Oncologues

Few data are available on second-line chemotherapy (CT2) for advanced biliary tract cancer (ABTC) CT2 might provide disease control for selected patie...

Lanreotide Autogel in the Treatment of Idiopathic Refractory Diarrhea: Results of an Exploratory, Controlled, Before and After, Open-label, Multicenter, Prospective Clinical Trial

Chronic idiopathic diarrhea is the passage of loose stools >3 times daily, or a stool weight >200 g/d. Patients refractory to standard anti-diarrhetic...

Implications of Infliximab Treatment Failure and Influence of Personalized Treatment on Patient-reported Health-related Quality of Life and Productivity Outcomes in Crohn's Disease

59 Crohn's disease patients with IFX treatment failure were randomized to an intensified IFX regimen or personalized treatment. Health-related quality...

Changes in serum trough levels of infliximab during treatment intensification but not in anti-infliximab antibody detection are associated with clinical outcomes after therapeutic failure in Crohn's disease

Intensification of the infliximab (IFX) regimen is recommended if the treatment effect is inadequate. The rationale for this is not well defined as th...

Physical Function and Spinal Mobility Remain Stable Despite Radiographic Spinal Progression in Patients with Ankylosing Spondylitis Treated with TNF-α Inhibitors for Up to 10 Years

Patients with ankylosing spondylitis were treated with tumor necrosis factor-alpha (TNF-α) inhibitors for up to 10 years. Spinal radiographs were scor...

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