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Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden
The use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD) Data for adults are mixed and smaller investigati...
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A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study
Non-invasive tests that can identify patients with non-alcoholic steatohepatitis (NASH) at higher risk of disease progression are lacking. We report t...
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Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial
Cobitolimod is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9) It's a promising novel therapeutic targe...
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Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis
Previous estimates of the magnitude of this issue have not accounted for ongoing inflammation as the potential cause. Of 3370 studies identified, 27 w...
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Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis
Tenofovir disoproxil fumarate and entecavir differ in their association with the risk of hepatocellular carcinoma. Treatment should be guided by patie...
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Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis
WHO has set targets for hepatitis C virus (HCV) elimination by 2030. We looked at studies published and listed on MEDLINE or Embase between 2000 and 2...
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Efficacy of surgical or endoscopic treatment of idiopathic achalasia: a systematic review and network meta-analysis
The efficacy of treatments such as Heller's myotomy and per-oral endoscopic myotomy is unknown. We searched Cochrane Central Register of Controlled Tr...
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Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial
DosisPHERE-01 was a multicentre, open-label phase 2 trial done at four health-care centers in France. Patients had unresectable locally advanced hepat...