Smoking, Genetic Predisposition, and Colorectal Cancer Risk
Smoking and genetic predisposition are established risk factors for colorectal cancer. A PRS above the 90th percentile was significantly associated wi...
Preconception genome medicine: current state and future perspectives to improve infertility diagnosis and reproductive and health outcomes based on individual genomic data
Our genetic code is now readable, writable, and hackable. Extension of reproductive genetic risk assessment to the general population and IVF couples...
Tazemetostat for patients with relapsed or refractory follicular lymphoma: an open-label, single-arm, multicentre, phase 2 trial
Activating mutations of EZH2, an epigenetic regulator, are present in 20% of follicular lymphoma patients. Tazemetostat monotherapy showed clinically...
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of surviva...