Probiotics for Constipation in Parkinson Disease: A Randomized Placebo-Controlled Study
In a double-blind, placebo-controlled trial, 280 patients with PD were screened. 72 eligible patients were randomly assigned to receive probiotics or...
The vitamin D for COVID-19 (VIVID) trial: A pragmatic cluster-randomized design
High-dose vitamin D3 supplementation will reduce the risk of hospitalization/death among those with COVID-19 infection. The study involved 1500 newly...
Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial
This is the first randomized placebo-controlled trial to test the effect of the KCQ2-2 positive modulator ezogabine on reward circuit activity and out...
Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial
The multicentre, double-blind, placebo-controlled, randomized trial was done at 386 study sites in 21 countries. The relative risk reduction for the p...
Effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate in patients with heart failure (Empire HF Renal): a prespecified substudy of a double-blind, randomised, placebo-controlled trial
SGLT2 inhibitors are a promising treatment option in patients with heart failure. The Empire HF trial is registered with ClinicalTrials.gov and EudraC...
The effect of vitamin D supplementation on acute respiratory tract infection in older Australian adults: an analysis of data from the D-Health Trial
We used data from the D-Health Trial, a randomized, double-blind, placebo-controlled trial of vitamin D supplementation. Vitamin D supplementation did...
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