Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study
Cognitive impairment associated with schizophrenia predicts poor functional outcomes. Currently, no approved pharmacotherapy is available. This study...
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
E3-ubiquitin ligase Cullin3 (Cul3) is a high confidence risk gene for autism spectrum disorder (ASD) and developmental delay (DD) We generated a hapl...
Improving Suicide Prevention Through Evidence-Based Strategies: A Systematic Review
Teaching youths about depression and suicidal behavior can prevent suicide. Ketamine reduces suicidal ideation in hours but is untested for suicidal b...
Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis
The study compared relapse prevention and acceptability of long-acting injectable (LAI) antipsychotics in the maintenance treatment of adults with non...
Association Between Benzodiazepine or Z-Drug Prescriptions and Drug-Related Poisonings Among Patients Receiving Buprenorphine Maintenance: A Case-Crossover Analysis
Benzodiazepine and Z-drug use is linked with drug-related poisonings among patients receiving buprenorphine maintenance treatment. Buprenorphine's ass...
Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results From a Randomized Controlled Trial
This is the first randomized placebo-controlled trial to test the effect of the KCQ2-2 positive modulator ezogabine on reward circuit activity and out...
Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Adolescent depression is prevalent and associated with significant morbidity and mortality. 17 adolescents with a diagnosis of major depressive disord...
Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population
The potential impact of the COVID-19 pandemic on population mental health is of increasing global concern. Mental health was assessed using the 12-ite...
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