Effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate in patients with heart failure (Empire HF Renal): a prespecified substudy of a double-blind, randomised, placebo-controlled trial
SGLT2 inhibitors are a promising treatment option in patients with heart failure. The Empire HF trial is registered with ClinicalTrials.gov and EudraC...
Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial
A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but i...
The effect of flexible assertive community treatment in Denmark: a quasi-experimental controlled study
Flexible assertive community treatment is a community-based treatment model for severe mental illness. It has been widely implemented despite little e...
Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study
Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promis...
Global costs, health benefits, and economic benefits of scaling up treatment and imaging modalities for survival of 11 cancers: a simulation-based analysis
Treatment, imaging, and quality of care could avert 12% of cancer deaths globally, ranging from 2% in high-income countries to 38% in low-income natio...