Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial

A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but i...

The effect of flexible assertive community treatment in Denmark: a quasi-experimental controlled study

Flexible assertive community treatment is a community-based treatment model for severe mental illness. It has been widely implemented despite little e...

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study

Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promis...

Global costs, health benefits, and economic benefits of scaling up treatment and imaging modalities for survival of 11 cancers: a simulation-based analysis

Treatment, imaging, and quality of care could avert 12% of cancer deaths globally, ranging from 2% in high-income countries to 38% in low-income natio...