Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction
Cardiac hypertrophy is a compensatory response to pressure overload leading to heart failure. We identified the pivotal roles of the mammalian homolog of Drosophila diaphanous (mDia) 1, a Rho-effector molecule, in pressure overload-induced ventricular hyperTrophy.
