Circulating collagen neo-epitopes and their role in the prediction of fibrosis in patients with systemic sclerosis: a multicentre cohort study
Extracellular matrix remodeling is a hallmark of systemic sclerosis. Matrix neo-epitopes could be used in clinical practice to risk-stratify patients at risk of fibrosis. The turnover ratio of type IV collagen predicted skin progression in a multivariable model adjusted for modified Rodnan skin score, sex, and age.
