Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study
Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the alpha-synucleinopathies Parkinson's disease and dementia with Lewy bodies. Real-time quaking-induced conversion analysis of CSF has high sensitivity and specificity for the detection of misfolded alpha-synuclein. 52 patients with IRBD and 40 healthy controls underwent lumbar puncture between March 23, 2008, and July 16, 2017.
