Circulating plasmablasts and high level of BAFF are hallmarks of minimal change nephrotic syndrome in adults
The Recent success achieved with the use of B cell-depleting agents in some patients with minimal change nephrotic syndrome. An increase in circulating plasmablasts seems to be a hallmark of untreated MCNS in adult patients. Increased production of interleukin (IL)-21, IL-6 and B- cell-activating factor was found significantly correlated with the percentage of plasmablast. An increase in circulating plasmablasts seems to be a hallmark of untreated MCNS in adult patients.
