Urinary chloride concentration and progression of chronic kidney disease: results from the KoreaN cohort study for Outcomes in patients With Chronic Kidney Disease
Urinary chloride is regulated by kidney transport channels. High urinary chloride concentration in the distal tubules can trigger tubuloglomerular feedback. Little attention has been paid to urinary chloride as a biomarker of clinical outcomes. We studied the relationship between urinary chloride concentration and chronic kidney disease. For every 25 mEq/L increase in urinary chloride, there was an 11% lower risk for CKD progression. Low urinary chloride concentration was associated with a highe
