Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma

Esophagectomy is the standard treatment for stage I esophageal squamous cell carcinoma. A combination of ER and selective CRT was confirmed to be a mi...

Adalimumab Monotherapy and a Combination with Azathioprine for Crohn's Disease: A Prospective, Randomized Trial

The study evaluated the efficacy of adalimumab with and without azathioprine in patients with active Crohn's disease. The rate of endoscopic improveme...

Randomized phase III study of bevacizumab plus FOLFIRI and bevacizumab plus mFOLFOX6 as first-line treatment for patients with metastatic colorectal cancer (WJOG4407G)

WJOG4407G was a randomized, open-label, phase III trial conducted in Japan. Patients with previously untreated mCRC were randomized 1:1 to receive FOL...

Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: A Systematic Review and Meta-analysis

It is not clear whether approved low-volume polyethylene glycol (PEG) regimens are as effective as high-volume PEG regimens when taken in a split dose...

Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study

Pediatric patients aged 4-17 years with newly diagnosed ulcerative colitis were recruited from 29 centers in the USA and Canada. The primary outcome w...

Quality of meta-analyses in major leading gastroenterology and hepatology journals: A systematic review

Country, a number of patients, funding sources were also revealed. Publication in recent years showed a significantly better methodological quality th...

Gut Microbiota in Patients With Irritable Bowel Syndrome-A Systematic Review

Altering the gut microbiota has been proposed as a strategy for the treatment of IBS. Family Enterobacteriaceae (phylum Proteobacteria) and genus Bac...

The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes

Pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndromes. We aimed to clarify the...

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