Advanced endoscopy fellowship training in the United States: recent trends in American Society for Gastrointestinal Endoscopy advanced endoscopy fellowship match, trainee experience, and postfellowship employment

AEF match offers a structured application process for AEF training in the U.S. Number of AEF match applicants increased by 15.6% (90 in 2012 to 104 in...

TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study

Gliadin protein (gliadin) encapsulated in negatively charged poly(dl-lactide-co-glycolic acid) nanoparticles is designed to induce gluten-specific tol...

Ethnicity associations with food sensitization are mediated by gut microbiota development in the first year of life

In this study, we characterized the composition of fecal microbiota in 1422 Canadian full-term infants. Atopic sensitization outcomes were measured by...

Fully Covered Self-Expanding Metal Stent versus Multiple Plastic Stents to Treat Benign Biliary Strictures Secondary to Chronic Pancreatitis: A Multicenter Randomized Trial

Benign biliary strictures are complications of chronic pancreatitis. The study compared 12-month treatment with MPS and FCS EMS. At 24 months, MPS tre...

Gluten Degradation, Pharmacokinetics, Safety, and Tolerability of TAK-062, an Engineered Enzyme to Treat Celiac Disease

Celiac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten. TAK-062 is a novel, computationally designed endopeptidase u...

Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 1988 to 2012 worldwide

Gastric cancer still represents a major cancer burden worldwide. Persistent decreasing trends in gastric cancer incidence rates were observed from 198...

Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer

The authors conducted a patient-centered functional genomics platform that includes approximately 200 genes. Administration of KPT-8602, an XPO1 inhib...

Deleterious variants in ABCC12 are detected in idiopathic chronic cholestasis and cause intrahepatic bile duct loss in model organisms

CRISPR/Cas9 genome editing was employed to induce pathogenic variants in the candidate gene. MRP9-deficient mice had fewer well-formed interlobular bi...

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