Familial burden and other clinical factors associated with various types of cancer in individuals with Lynch syndrome

LS is associated with increased risks of various gastrointestinal, gynecologic, genitourinary, and other cancers. Many clinical practice guidelines re...

Outcomes of thermal ablation of the mucosal defect margin after endoscopic mucosal resection: A prospective, international, multi-centre trial of 1000 large non-pedunculated colorectal polyps

Thermal ablation of the defect margin after endoscopic mucosal resection has shown efficacy in a randomized trial with a four-fold reduction in residu...

A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer

Study: Translates tissue-based biomarkers into a blood-based liquid biopsy for noninvasive detection of lymph node metastasis. The Risk-stratification...

Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine

Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Pruritogenicity of LPC, LPA's precursor, was...

BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes

Pancreatic ductal adenocarcinoma (PDAC) has different subtypes and their correlation with patient outcomes. B-cell CLL/lymphoma 3 (BCL3) was significa...

BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration

Intestinal regeneration is underpinned by dedifferentiation and cell plasticity. We spatiotemporally mapped BMP signaling in mouse and human regenerat...

Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study

Radical surgery via total mesorectal excision might not be the optimal first-line treatment for early-stage rectal cancer. Serious adverse events asso...

Association of inflammatory markers with the severity of COVID-19: A meta-analysis

Study: Studies reported associations of inflammatory markers with the severity of COVIUD-19, but conclusions were inconsistent. Measurement of inflamm...

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