Artificial Intelligence System to Determine Risk of T1 Colorectal Cancer Metastasis to Lymph Node

Most patients with T1 colorectal cancers undergo surgical resection with lymph node dissection. There is a low incidence of metastasis to lymph nodes....

Colonoscopist Performance and Colorectal Cancer Risk After Adenoma Removal to Stratify Surveillance: Two Nationwide Observational Studies

Colonoscopy surveillance after adenoma removal is an increasing burden in many countries. Surveillance recommendations consider characteristics of rem...

Sofosbuvir plus ribavirin and sofosbuvir plus ledipasvir in patients with genotype 1 or 3 hepatitis C virus and severe renal impairment: a multicentre, phase 2b, non-randomised, open-label study

There is a medical need for highly effective, safe, and well-tolerated treatments for patients infected with hepatitis C virus (HCV) Eight patients ha...

Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: a systematic review and meta-analysis

Irritable bowel syndrome (IBS) is one of the most common functional bowel disorders. Community prevalence appears to vary widely between different cou...

Standard gastroenterologist versus multidisciplinary treatment for functional gastrointestinal disorders (MANTRA): an open-label, single-centre, randomised controlled trial

Outcomes were assessed at clinic discharge or 9 months after the initial visit. The primary outcome was a score of 4 or 5 on a 5-point Likert scale as...

Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study

Liver transplantation did not significantly increase the risk of death in patients with SARS-CoV-2 infection. Increased age and presence of comorbidit...

Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial

Lubiprostone was well tolerated and reduced the levels of liver enzymes in patients with NAFLD and constipation. The most common adverse event was dia...

Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden

The use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD) Data for adults are mixed and smaller investigati...

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