A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study

Non-invasive tests that can identify patients with non-alcoholic steatohepatitis (NASH) at higher risk of disease progression are lacking. We report t...

Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial

Cobitolimod is a topically administered, DNA-based oligonucleotide that activates Toll-like receptor 9 (TLR9) It's a promising novel therapeutic targe...

Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis

Previous estimates of the magnitude of this issue have not accounted for ongoing inflammation as the potential cause. Of 3370 studies identified, 27 w...

Hepatocellular carcinoma incidence with tenofovir versus entecavir in chronic hepatitis B: a systematic review and meta-analysis

Tenofovir disoproxil fumarate and entecavir differ in their association with the risk of hepatocellular carcinoma. Treatment should be guided by patie...

Prevalence and incidence of hepatitis C virus infection in men who have sex with men: a systematic review and meta-analysis

WHO has set targets for hepatitis C virus (HCV) elimination by 2030. We looked at studies published and listed on MEDLINE or Embase between 2000 and 2...

Efficacy of surgical or endoscopic treatment of idiopathic achalasia: a systematic review and network meta-analysis

The efficacy of treatments such as Heller's myotomy and per-oral endoscopic myotomy is unknown. We searched Cochrane Central Register of Controlled Tr...

Personalised versus standard dosimetry approach of selective internal radiation therapy in patients with locally advanced hepatocellular carcinoma (DOSISPHERE-01): a randomised, multicentre, open-label phase 2 trial

DosisPHERE-01 was a multicentre, open-label phase 2 trial done at four health-care centers in France. Patients had unresectable locally advanced hepat...

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial

Early studies suggest extensive intraoperative peritoneal lavage (EIPL) might reduce the risk of recurrence. We aimed to evaluate the survival benefit...

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