The Cardiac Late Sodium Channel Current is a Molecular Target for the Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin

Sodium/glucose co-transporter 2 SGLT2 inhibitors exert cardioprotective effects against heart failure in diabetes patients. There is intense interest...

Endothelium-restricted endothelin-1 overexpression in type 1 diabetes worsens atherosclerosis and immune cell infiltration via NOX1

Endothelin (ET)-1 has been implicated in diabetes-induced vascular complications. ET-1 overexpression increased 2.5-fold and five-fold the atheroscler...

Remote ischaemic preconditioning ameliorates anthracycline-induced cardiotoxicity and preserves mitochondrial integrity

Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. The central mechanism of AIC is irreversible mitochondri...

Dilated cardiomyopathy-linked heat shock protein family D member 1 mutations cause up-regulation of reactive oxygen species and autophagy through mitochondrial dysfunction

During heart failure, levels of circulatory heat shock protein family D member 1 increase. Mutations in HSPD1 cause mitochondrial dysfunction and indu...

Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction

Cardiac hypertrophy is a compensatory response to pressure overload leading to heart failure. We identified the pivotal roles of the mammalian homolog...

Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts

Ca2+ leak in atrial myocytes plays an essential role in the development of atrial fibrillation (AF) Leak is induced by mechanical stretch due to eleva...

Ventricular fibrillation mechanism and global fibrillatory organization are determined by gap junction coupling and fibrosis pattern

Conflicting data exist supporting differing mechanisms for sustaining ventricular fibrillation. Abnormal gap junction (GJ) coupling and fibrosis are i...

Deletion of fibroblast activation protein provides atheroprotection

Fibroblast activation protein (FAP) is upregulated at sites of tissue remodeling including chronic arthritis, solid tumors, and fibrotic hearts. It ha...

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