Molecular Mechanisms of Diaphragm Myopathy in Humans With Severe Heart Failure

Diaphragm weakness impairs quality of life, exercise capacity, and survival in patients with chronic heart failure (CHF) and reduced left ventricular...

Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device

Heart rate–corrected QT interval (QTc) prolongation can predispose to ventricular arrhythmias and sudden cardiac death. Currently, QTc assessment and...

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of UK deaths. Short telomere length is associated with IPF and chronic o...

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial

Biological considerations suggest that renin-angiotensin system inhibitors might influence the severity COVID-19 Replace trial was a prospective, open...

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

ANDHI was done to assess the efficacy of bevacizumab in treating severe eosinophilic asthma. It was a randomized, double-blind, parallel-group, placeb...

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Influenza epidemics have been considered suitable for use as a model for the COVID-19 epidemic. In-hospital mortality was higher in patients with. COV...

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction. Benzodiazepine use...

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