Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial
Adjuvant radiotherapy has been shown to halve the risk of biochemical progression for patients with high-risk disease after radical prostatectomy. Sal...
Carfilzomib or bortezomib in combination with lenalidomide and dexamethasone for patients with newly diagnosed multiple myeloma without intention for immediate autologous stem-cell transplantation (ENDURANCE): a multicentre, open-label, phase 3, randomised, controlled trial
Carfilzomib, a next-generation proteasome inhibitor, in combination with lenalidomide and dexamethasone has shown promising efficacy in phase 2 trials...
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study
The study investigated COVID-19 risk according to tumor type and patient demographics in patients with cancer in the UK. 319 out of 1044 patients died...
Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial
CTDNA testing might provide an assessment of the genomic profile of advanced cancer without the need to repeat tumor biopsy. We did an open-label, mul...
Trastuzumab emtansine plus atezolizumab versus trastuzumab emtansine plus placebo in previously treated, HER2-positive advanced breast cancer (KATE2): a phase 2, multicentre, randomised, double-blind trial
Addition of atezolizumab to trastuzumab emtansine might potentiate anticancer immunity and enhance the HER2-targeted cytotoxic activity. The KATE2 stu...
Veliparib with carboplatin and paclitaxel in BRCA-mutated advanced breast cancer (BROCADE3): a randomised, double-blind, placebo-controlled, phase 3 trial
BRCA1 or BRCA2-mutated breast cancers are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. BROCADE3 was a randomized, double-blind, placebo...
Gamma knife radiosurgery for uveal melanomas and metastases: a systematic review and meta-analysis
Gamma knife radiosurgery is used to treat intracranial tumours and intraocular malignancies. We searched MEDLINE and Embase for studies published betw...
Quality of life in patients with metastatic prostate cancer following treatment with cabazitaxel versus abiraterone or enzalutamide (CARD): an analysis of a randomised, multicentre, open-label, phase 4 study
Cabazitaxel significantly improved radiographic progression-free survival and overall survival in the CARD study. The study involved 62 clinical sites...
Recent Posts
-
-
What Causes Sciatica | Dr. Kalyan Bommakanti
11 May 2022 -
