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Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial

This randomized, controlled, phase 3, superiority, trial was done at 17 hospitals in nine provinces of China. Eligible patients were aged 18–75 years...

Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial

This multicentre, open-label, randomized, controlled, phase 3 trial was done in three hospitals in China. The primary endpoint was overall survival, c...

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study

Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promis...

Comparison of breast cancer and cervical cancer stage distributions in ten newly independent states of the former Soviet Union: a population-based study

More than 50% of breast cancer cases across the region were at stages I–II. The proportion of stage I cases was highest in the screening age group of...

Pyrotinib plus capecitabine versus lapatinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, open-label, randomised, controlled, phase 3 trial

This is an open-label, randomized, controlled, phase 3 trial done at 29 hospitals in China. Patients had pathologically confirmed HER2-positive metast...

Global costs, health benefits, and economic benefits of scaling up treatment and imaging modalities for survival of 11 cancers: a simulation-based analysis

Treatment, imaging, and quality of care could avert 12% of cancer deaths globally, ranging from 2% in high-income countries to 38% in low-income natio...

High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial

This open-label, randomised, phase 2 trial was done at 22 public hospitals in Norway, Denmark, and Sweden. At 2 years, 66% of patients in the 60 Gy gr...

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