Incidence and Management of Carfilzomib-induced Cardiovascular Toxicity; A Systematic Review and Meta-analysis
8.9% sustained all grade cardiotoxicity, while 4.4% sustained high-grade cardiotoxicity with carfilzomib. All-grade hypertension was present in 13.2% of patients. No difference in the event rate between newly diagnosed multiple myeloma patients and those with relapsed/refractory cancer.

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