Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study

26 Mar 2021
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Rheumatology

Otilimab inhibits granulocyte-macrophage colony-stimulating factor (GM-CSF) This is a key driver in immune-mediated inflammatory conditions. We aimed to evaluate the efficacy, safety, and key patient-reported outcomes related to pain in patients with active rheumatoid arthritis.

Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study

Source: The Lancet

Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device

Heart rate–corrected QT interval (QTc) prolongation can predispose to ventricular arrhythmias and sudden cardiac death. Currently, QTc assessment and monitoring rely on 12-lead electrocardiography. We sought to train and validate an artificial intelligence (AI)–enabled. It could be cost-effective.

Source: American Heart Association.

Progressive learning in endoscopy simulation training improves clinical performance: a blinded randomized trial

A progressive learning-based curriculum (PLC) led to superior clinical performance compared with an SCC. PLC comprised 6 hours of SBT, which progressed in complexity and difficulty.

Source: National Library Of Medicine

Parents’ Experiences of Having a Young Child With Acute Lymphoblastic Leukemia in China

parents’ experiences are a prerequisite to developing interventions that are sensitive to the needs of children and families. Little is known about parental experiences of having a young child with acute lymphoblastic leukemia Ten parents, recruited in central China using purposive sampling, participated face-to-face. Support services to strengthen specific families' protective factors are needed. Public education and advocacy about cancer are also necessary to decrease cancer-related stigma and

Source: Journal Of Pediatric Oncology Nursing

SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis

SARS-CoV-2 has been arguably the most important public health concern worldwide in 2020. We used a random-effects model to estimate pooled seroprevalence and then extrapolated the findings to the global population (for 2020) This study showed that SARS- virus-2 seroprevalence varied markedly among geographic regions, as might be expected early in a pandemic.

Source: National Library Of Medicine

Propofol vs midazolam plus fentanyl for upper gastrointestinal endomicroscopy: a randomized trial

There were significantly more good quality endomicroscopic images in the propofol group than in the M/F group. The diagnostic accuracy for upper gastrointestinal mucosal lesions favors the P group. Adverse events and patient assessment were not significantly different for M/f vs propofols.

Source: National Library Of Medicine

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium.

Source: Lancet

MRI Brain Templates of the Male Yucatan Minipig

The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently, however, there is a lack of appropriate brain templates to support functional and structural neuroimaging pipelines.

Source: ELSEVIER

Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review

Computational methods of drug repurposing offer the best chance of selecting one drug from a list of approved drugs. Studies included repurposed drugs mainly against non-structural proteins of SARS-Co

Source: National Library Of Medicine

The impact of wire caliber on ERCP outcomes: a multicenter randomized controlled trial of 0.025-inch and 0.035-inch guidewires

Wire-guided biliary cannulation has been demonstrated to improve cannulation rates and reduce post-ERCP pancreatitis (PEP) This study compares successful cannulation. rates and ERCP adverse events by using a 0.025-inch and 0.035-inch guidewire. The primary outcomes of the study were successful wire-guided cannulation and the incidence of PEP.

Source: National Library Of Medicine

Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study

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Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study

Artificial Intelligence–Enabled Assessment of the Heart Rate Corrected QT Interval Using a Mobile Electrocardiogram Device

Progressive learning in endoscopy simulation training improves clinical performance: a blinded randomized trial

Parents’ Experiences of Having a Young Child With Acute Lymphoblastic Leukemia in China

SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis

Propofol vs midazolam plus fentanyl for upper gastrointestinal endomicroscopy: a randomized trial

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

MRI Brain Templates of the Male Yucatan Minipig

Computational drug discovery and repurposing for the treatment of COVID-19: A systematic review

The impact of wire caliber on ERCP outcomes: a multicenter randomized controlled trial of 0.025-inch and 0.035-inch guidewires

Efficacy, patient-reported outcomes, and safety of the anti-granulocyte macrophage colony-stimulating factor antibody otilimab (GSK3196165) in patients with rheumatoid arthritis: a randomised, phase 2b, dose-ranging study

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