A single-cell map for the transcriptomic signatures of peripheral blood mononuclear cells in end-stage renal disease
Immune aberrations in End-stage renal disease are characterized by systemic inflammation and immune deficiency. Study compared cells from ESRD patients and healthy individuals. Compared cells revealed multiple changes in biological processes. An increase in inflammation response, complement cascade, and cellular metabolism was observed. The generation of larger single-cell datasets will complement the current map and drive advances in therapies that manipulate immune cell function in ESRD.
