Contact dermatitis associated with preservatives: Retrospective analysis of North American Contact Dermatitis Group data, 1994 through 2016
The study looked at patch testing results of preservatives from 1994 through 2016. The most frequent reactions were to methylisothiazolinone 0.2% aqueous and formaldehyde 2% aq. Only one preservative had a significant increase in PPTRs over time.

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