The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification
In chronic kidney disease, serum phosphorus (P) elevations stimulate parathyroid hormone (PTH) production. PTH is the main regulator of the receptor activator of the nuclear factor B (RANK/RANK ligand) system. It is essential for bone maintenance and plays an important role in vascular smooth muscle cell calcification.
