Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis
Alcoholic hepatitis (AH) is a common but life-threatening disease with limited treatment options. Neutrophils in contact with bile ducts were quantified in liver biopsies from patients with AH and controls and correlated with clinical and pathological findings. Cholangiocytes co-cultured with neutrophils lost ITPR3, an apical intracellular calcium channel necessary for cholang iocytes' secretion. This previously unrecognised role alters our understanding of the disease and identifies new therape
