Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials
Study looked for randomized controlled trials that examined the efficacy and safety of gastrointestinal bleeding prophylaxis with PPIs, H2RAs, or sucralfate vs. one another or placebo. Findings: Both PPIs and H 2RAs probably reduce clinically important gastrointestinal bleeding. The magnitude of reduction is probably greater in PPIs than H2 RAs, and the difference may be important in higher, but not lower bleeding risk patients. The possibility that PPIs may slightly increase mortality can't be
