Efficacy of Oral, Topical, or Combined Oral and Topical 5-Aminosalicylates, in Ulcerative Colitis: Systematic Review and Network Meta-Analysis
5-aminosalicylates (5-ASAs) are the mainstay of treatment for ulcerative colitis (UC) The optimum preparation, dose, and route of administration for UC remains unclear. High-dose oral mesalazine was found to be more efficacious than lower doses. Future RCTs should better establish the role of combined therapy for induction of remission, as well as optimal doses of oral 5-ASA to prevent relapse.
