Trajectories of anxiety and depressive symptoms during enforced isolation due to COVID-19 in England: a longitudinal observational study

Anxiety and depression levels both declined across the first 20 weeks following the introduction of lockdown in England. Being a woman or younger, having lower educational attainment, lower-income, and living alone or with children were all risk factors.

Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62 354 COVID-19 cases in the USA

There are a range of physical health risk factors for COVID-19, but it is not known if there are also psychiatric risk factors. We used the TriNetX Analytics Network, a global federated network that captures anonymized data from electronic health records.

The mental health impact of the COVID-19 pandemic on people with and without depressive, anxiety, or obsessive-compulsive disorders: a longitudinal study of three Dutch case-control cohorts

The impact of the COVID-19 pandemic on mental health in people with pre-existing mental health disorders is unclear. We compared the perceived mental health impact and coping and changes in depressive symptoms, anxiety, worry, and loneliness before and during

Influence of methodological and patient factors on serum NMDAR IgG antibody detection in psychotic disorders: a meta-analysis of cross-sectional and case-control studies

Antibodies targeting the N-methyl-D-aspartate receptor (NMDAR) have been detected in patients with psychosis. It is unclear whether these antibodies are more common in patients than in controls. The effects of illness stage and study quality were not consistent across study designs.

Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis

Cerebral small vessel disease is a common cause of vascular dementia. It is often considered clinically silent before dementia or stroke becomes apparent. We aimed to determine whether neuropsychiatric and cognitive symptoms vary according to the burden of the disease burden.

Comparative efficacy and acceptability of psychological interventions for the treatment of adult outpatients with anorexia nervosa: a systematic review and network meta-analysis

We searched Cochrane CENTRAL, CINAHL, MEDLINE, and PsychINFO for published and unpublished literature from inception until March 20, 2020. Primary outcomes were changes in body mass index and clinical symptoms. The secondary outcome was the all-cause dropout rate. None of the interventions outperformed treatment as usual in our primary outcomes.

Clinical efficacy of a Decision Support Tool (Link-me) to guide intensity of mental health care in primary practice: a pragmatic stratified randomised controlled trial

Link-me is a patient-completed Decision Support Tool used to predict the severity of depression or anxiety. In this pragmatic stratified randomized controlled trial, adults aged 18–75 years reported depressive or anxiety symptoms or use of mental health medication. No serious adverse effects were recorded

Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study

New risk model to assess the benefits of adhering to a healthy lifestyle in individuals with a high genetic risk. The polygenic risk score derived from 112 single-nucleotide polymorphisms showed the strongest association with gastric cancer risk.

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