Transpancreatic biliary sphincterotomy versus double guidewire in difficult biliary cannulation: a randomized controlled trial

Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) increases the risk of post-ERCP pancreatitis (PEP) The study compared two advanced rescue methods, transpancreatic biliary sphincterotomy (TPBS) and a double-guidewire (DGW) technique in difficult common bile duct (CBD) cannulation. No difference existed in PEP severity between the groups.

Telomere length and risk of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease: a mendelian randomisation study

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease accounting for 1% of UK deaths. Short telomere length is associated with IPF and chronic obstructive pulmonary disease (COPD) There was no evidence to infer that telomeres caused COPD, however. Telomere shortening might be a contributory factor in IPF, suggesting divergent mechanisms in COPD. Investigation of therapies that improve telomere length is warranted.

Continuation versus discontinuation of renin–angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomised, open-label trial

Biological considerations suggest that renin-angiotensin system inhibitors might influence the severity COVID-19 Replace trial was a prospective, open-label trial done at 20 large referral hospitals in seven countries. 29% of participants in the continuation group and 28% in the discontinuation group had at least one adverse event. There was no difference in blood pressure, serum potassium, or creatinine during follow-up across the two groups. Renin–angiotensin system inhibitors can be safely co

Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial

ANDHI was done to assess the efficacy of bevacizumab in treating severe eosinophilic asthma. It was a randomized, double-blind, parallel-group, placebo-controlled study. The primary efficacy measure was annualized asthma exacerbation rate. Our results extend the efficacy profile of bevacizumab for patients with severe eosinophilic asthma, showing early clinical benefits in patient-reported outcomes, HRQOL, lung function, and nasal polyposis symptoms.

Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study

Influenza epidemics have been considered suitable for use as a model for the COVID-19 epidemic. In-hospital mortality was higher in patients with. COVID, with a relative risk of death of 2.9 (95% CI 2.8–3.0) In children, the rate of hospitalization for COVID-19 appears to be lower than for Influenza. These findings highlight the importance of appropriate preventive measures for COVID-19, as well as the need for a specific vaccine and treatment.

Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study

750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction. Benzodiazepine use and lack of family visitation were identified as modifiable risk factors for delirium.