Is there an association between peptic ulcer disease and osteoporosis: a systematic review and cumulative analysis

Peptic ulcer disease (PUD) sufferers are at a high risk of developing osteoporosis, but the evidence has not been previously synthesized. This is the first study to quantify the positive association between PUD and the risk of osteoporosis by conducting a meta-analysis. In clinical practice, assessment of the bone mineral density and antiosteoporotic treatments are recommended for those potential patients with PUD.

The role of endoscopic doppler probe in the management of bleeding peptic ulcers: a systematic review and meta-analysis

The endoscopic doppler probe (DOP-US) identifies arterial blood flow at the base to direct therapy. We performed a systematic review and meta-analysis to evaluate the role of the DOP- US in bleeding peptic ulcers. The use of the probe decreased rebleeding, mortality, and surgical intervention as compared to Forrest Classification.

Use of proton pump inhibitors to treat persistent throat symptoms: multicentre, double blind, randomised, placebo controlled trial

Lansoprazole was either given twice daily for 16 weeks or matched to placebo. Primary outcome was symptomatic response at 16 weeks measured using the total reflux symptom index (RSI) Secondary outcomes included symptom response at 12 months, quality of life, and throat appearances. No evidence was found of benefit from PPI treatment in patients with persistent throat symptoms. No statistically significant difference was found between the treatment arms for any secondary outcome measure, includin

Systematic Review and Meta-Analysis of Prophylactic Transarterial Embolization for High-Risk Bleeding Peptic Ulcer Disease

The present systematic review determined the role of transarterial embolization (TAE) as a prophylactic treatment in bleeding peptic ulcers. Patients who underwent ET with TAE had lower 30-day rebleeding rates and mortality rates. Technical success rate of TAE was 90.5% (95% CI, 83.09-97.98; I2 = 75.9%). Pooled proportion of overall complication rate was 0.18% ( 95% CI,. 0.00-1.28)

Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score

Bleeding after endoscopic submucosal dissection (ESD) is a frequent adverse event after early gastric cancer surgery. We aimed to develop and externally validate a clinically useful prediction model for bleeding after ESD for EGC. In a nationwide multicentre study, we derived and externally validated a prediction model. This model may be a good clinical decision-making support tool for ESD in patients with EGC, we say.

Global prevalence of Barrett’s oesophagus and oesophageal cancer in individuals with gastro-oesophageal reflux: a systematic review and meta-analysis

There has been no definitive systematic review and meta-analysis of data to estimate global prevalence of Barrett's oesophagus. Prevalence of BO among individuals with gastro-oesophageal reflux varied according to different geographical regions. Dysplasia was present in 13.9% of cases of histologically confirmed BO, 80.7% of which was low-grade. The prevalence of BO was significantly higher in men than in women.

Impact of disconnected pancreatic duct on recurrence of fluid collections and new-onset diabetes: do we finally have an answer?

Disconnected pancreatic duct (DPD) is a frequent occurrence in cases with walled-off necrosis (WON) The impact of DPD on recurrence of collection after removal of metal stents is not clear.The presence of DPD was a significant risk factor for the recurrence of fluid collections as well as new-onset DM

Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. We aimed to identify disease-relevant phenotypes associated with faecal microbiota (in-)stability. The greatest microbiome instability was associated with factors contributing to metabolic syndrome such as fatty liver disease and diabetes mellitus. Greatest stability of the microbiome was determined by higher initial alpha diversity, female sex and high household inc

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