Interventions for treating iron deficiency anaemia in inflammatory bowel disease

Iron deficiency anaemia can occur with a prevalence of up to 90%. It can significantly affect quality of life, both during periods of active disease or in remission. Intravenous ferric carboxymaltose probably leads to more people having resolution of IDA than intravenous iron sucrose, authors say. Oral ferric maltol may also lead to more patients having resolution than placebo, they say. No serious adverse events were specifically elicited with any of the treatments studied.`

The Adequacy of Habitual Dietary Fiber Intake in Individuals With Inflammatory Bowel Disease: A Systematic Review

Dietary fiber may influence disease course in individuals with inflammatory bowel disease (IBD) Yet there is a paucity of understanding of habitual fiber intakes of individuals with IBD. This study identified studies measuring fiber intakes. It compared fiber intakes with that of control groups or respective national dietary guidelines. Four studies reported that less than 10% to 21% of IBD participants met their national fiber recommendations.

Systematic review: the impact of inflammatory bowel disease-related fatigue on health-related quality of life

Fatigue is frequently reported in inflammatory bowel disease (IBD) and impacts on health-related quality of life. HRQoL has not been systematically reviewed in IBD fatigue. Psychosocial factors, symptom management and acceptance and physical activity levels have significant impact on HRQOL. Results support application of psychosocial or exercise interventions for fatigue management. Further exploration of HRQeL factors in IBS fatigue is required.

Therapeutic strategies for stricturing Crohn's disease in childhood: a systematic review

Childhood stricturing Crohn's disease (CD) has significant morbidity. Interventions including resection, stricturoplasty and endoscopic balloon dilatation (EBD) are often required. Optimal intervention modality and timing, and use of adjuvant medical therapies, remains unclear. We propose a minimum reported dataset for interventions in paediatric stricturing CD.

Surgical Management of Idiopathic Perianal Fistulas: A Systematic Review and Meta-Analysis

Perianal fistula is a common colorectal condition with an incidence of 9 per 100,000. No clear consensus exists as to what is the gold standard approach for treating it. This systematic review aimed to examine all available evidence pertaining to the surgical management of perianal fistulas.

Characterization of Mucosal Lesions in Crohn's Disease Scored With Capsule Endoscopy: A Systematic Review

There is little agreement on the nomenclature and description of Crohn's disease (CD) lesions that can be found in the small and large bowel using capsule endoscopy (CE) We performed a systematic review to identify mucosal lesions that have been described using CE in CD, in both the small bowel and colon. Ulcers and erosions were the most frequently described CD lesions.

Respiratory Tract Infections in Inflammatory Bowel Disease Patients Taking Vedolizumab: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

The ongoing COVID-19 pandemic has raised concerns about the risk of SARS-CoV-2 infection. Vedolizumab is used to treat Crohn's disease (CD) and ulcerative colitis (UC) patients taking immunosuppressants or biologics. Eight RCTs involving 3,287 patients (1873 CD and 1415 UC) were analyzed. The rates of RTI and URTI were statistically higher in vedolizumab-treated patients compared to placebo. The number of LRTI was small in both treatment groups.

Upper gastrointestinal mucosal injury associated with ticagrelor plus aspirin, ticagrelor alone, or aspirin alone at 1-year after coronary artery bypass grafting

The presence and severity of upper gastrointestinal mucosal lesions have not been evaluated using esophagogastroduodenoscopy (EGD) in patients receiving ticagrelor plus aspirin or alone after myocardial revascularization. Eighty-eight (38.1%) patients had a positive 13 C urea breath testing after 1 year of treatment after CABG. Severe upper gastrointestinal lesions were more frequently observed in patients treated with ticgrelor plus aspirin and aspirin monotherapy. Prophylactic use of PPIs migh