Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial
Testosterone treatment for 2 years reduced the proportion of participants with type 2 diabetes beyond the effects of a lifestyle programme. The treatment effect was independent of baseline serum testosterone. Longer-term durability, safety, and cardiovascular effects of the intervention remain to be further investigated.
