Smoking, Genetic Predisposition, and Colorectal Cancer Risk
Smoking and genetic predisposition are established risk factors for colorectal cancer. A PRS above the 90th percentile was significantly associated with a 3.6-, 4.3-, and 6.4-fold increased risk. Smoking and the PRS carry essentially independent CRC risk information. Abstinence from smoking can compensate for a substantial proportion of genetically determined CRC risk.
